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Lifestyle modifications should become habitual: Consistent meal timing helps regulate digestive patterns Stress management through mindfulness, yoga, or other relaxation techniques, as stress can exacerbate gastrointestinal symptoms Regular physical activity (150 minutes moderate-intensity per week, as per UK Chief Medical Officers' guidelines) supports both weight management and digestive health Adequate sleep (79 hours nightly) influences gut hormone regulation Monitoring and review should include: Regular weight and BMI measurements Assessment of comorbidity improvement (blood pressure, HbA1c if diabetic, lipid profile) Evaluation of side effect burden and impact on daily functioning Treatment continuation assessmentthe MHRA/EMC SmPC advises discontinuation if weight loss is less than 5% after 12 weeks at the 3.0 mg dose Pharmacological adjuncts may occasionally be appropriate

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Rebouche CJ, Engel AG