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Folic acid, which is the form found in fortified foods and supplements is also a poor substrate for folylpolyglutamate synthase accounting for its efficient uptake from the intestines and release to the blood

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10.3390/ijms2403296036769281 345 Batty M, Bennett MR, Yu E

The randomization schedule was generated by the statistical analysis unit using SAS (version 9.4 or above), employing a block randomization method to assign each subject to either the T1-T2 or T2-T1 group