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MKRN3 seems to be involved in regulating the hypothalamic-pituitary-gonadal axis by inhibiting the release of gonadotropin-releasing hormone (GnRH) and contributing to the control of puberty onset ( MAGEL2 encodes the melanoma antigen L2, a member of the Melanoma Antigen Gene (MAGE) family of ubiquitin ligase regulators

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