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In addition to the diffusion and bulk flow theory, other theories have also been proposed, such as the osmoelectric siphon model, which is based on membrane depolarization leading to cell water shedding into the apoplast followed by membrane repolarization and water uptake 43

Therefore, in the absence of significant active uptake transporter action, liver microsomes are more accurate ( in vivo experiments, and save development time and costs ( Physiologically-based pharmacokinetic (PBPK) and metabolism patterns are used to predict and explain the differences in ADME properties of drugs among individuals, which are crucial for simplifying drug formulation development and regulatory evaluation ( in silico (distribution) and CL and provide a predictable process of the overall PK profile, which applies in the pharmaceutical industry constantly ( in vivo PK behavior of drugs ( in vivo , as well as the effects of disease and physiological factors on PK behavior