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doi: 10.1146/ANNUREV-BIOCHEM-060815-014442 216 LiangDLiFFuYCaoYSongXWangTet al

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NOX4-mediated promotion mechanism The NOX enzyme family, encompassing seven isoforms (NOX1 to NOX5, DUOX1 and DUOX2), is pivotal for generating ROS, which are integral to cellular signaling, host defense and redox balance maintenance (92,93)