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Through MAPK and increased gonadotropin-releasing hormone (GnRH) gene expression, it increases the frequency and amplitude of GnRH release pulses and, in consequence, LH release, which stimulates ovarian cells to androgen synthesis [64]

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Specific Causation A successful GLP-1 claim requires proof of both: General causation : Whether the drug is capable of causing the alleged injury Specific causation : Whether the drug actually caused the injury in the individual plaintiff Scientific literature, pharmacovigilance data, and regulatory findings are critical in establishing general causation