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This combination promotes the increase of GH by both increasing the strength of the GH release pulse and increasing the number of cells that secrete GH with the two pathways converging on the somatotroph to produce a supraphysiological GH response that neither compound achieves independently

Patients are randomized to pemvidutide 1.2 or 1.8 mg weekly, or placebo for 24 weeks, with primary endpoints of MASH resolution without fibrosis progression and fibrosis amelioration without MASH deterioration

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