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Risks can include nausea, gastrointestinal upset, gallbladder issues, and, in some cases, concerns about overrapid weight loss or muscle loss if nutrition and strength training are not prioritized

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Key points The repertoire of gastrointestinal metabolites is determined by a combination of dietary, host-derived and microbial contributions

The dose may be increased at 4- to 8-week intervals according to individual patient requirements to a maximum of 0.08 mg/kg/week, depending upon patient tolerance of treatment