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Substantial or rapid weight loss can increase the risk of cholelithiasis

However, LVF triple therapy is not recommended as a first-line choice for most patients because resistance to LVF is increasing worldwide, but in areas of low LVF resistance and high CLR and MTZ resistance or unavailability of bismuth, this therapy can be used (OMorain et al

In fact, this form is common as an antidote for cyanide toxicity

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