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MASH improvement (no fibrosis worsening) at 2.4mg: 47% MASH improvement (no fibrosis worsening) at 4.8mg: 62% MASH improvement (no fibrosis worsening) at 6.0mg: 43% Placebo MASH improvement: 14% Liver fat reduction of 30%+ at 4.8mg: 67% Fibrosis improvement by 1+ stage: 34-36% These results led to FDA Breakthrough Therapy designation, which accelerates the development and review process for drugs addressing serious conditions

others show slower increases, reflecting variation in metabolic flexibility and baseline GLP-1R expression

It works by mimicking the effects of a hormone called GLP-1, which helps regulate blood sugar levels

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