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Subsequently, steroid glycoside H.g.-12, extracted from the plant Hoodia gordonii [which tastes bitter, and has potent appetite-suppressant effects in both animals and humans (64)] was found to induce CCK secretion both ex vivo from rat intestine, and from HuTu-80 cells ( ad libitum meal in healthy young individuals (62)

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Thymosin-4 (TB4 or TB-500)

RER Respiratory Exchange Ratio Glucose and insulin tolerance tests confirmed improved glucose tolerance, insulin sensitivity, and reduced systemic insulin levels, indicating normalized glucose metabolism (FIG.6A-6C)