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Native rhIGF-1 (mecasermin, brand name Increlex) is FDA-approved only for the long-term treatment of growth failure in pediatric patients with severe primary IGF-1 deficiency or with GH gene deletion who have developed neutralizing antibodies to GH

The occurrence of lanthionine motifs generated in bio-structures by intramolecular covalent attachment of cysteine or by reaction with glutathione has been identified as a marker of protein aging [62,126,207,208,209]

Consult before use if taking medication, managing a medical condition, or planning surgery

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