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doi: 10.1093/carcin/bgn188 131 MorozOVAntsonAAGristSJMaitlandNJDodsonGGWilsonKSet al

For this reason, EASL guidelines suggest prudentially an individualized follow-up every three years for asymptomatic family members and first-degree relatives of heterozygous parents with severe MDR3 deficiency, even if they have normal laboratory values and no signs of advanced liver fibrosis or gallstone disease [68]