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The proteins encoded by these genes have diverse functions, including promoting GSH synthesis, regenerating NADPH and upregulating iron storage proteins (ferritin), thereby constructing a robust, multilayered defense against ferroptosis (32)

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Mechanistically, siNrf2 transfection reverses these effects, indicating that Nrf2 mediates the proapoptotic effects of Res on fibroblast-like synoviocytes

It may feel like a more approachable starting point than surgery as it doesn't require hospitalization or recovery time, and it can begin producing results relatively quickly