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5-Amino-1MQ functions as a small-molecule inhibitor of NNMT, the enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, producing 1-methylnicotinamide

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[3] [6] If no reversible cause is found, or when found it cannot be eliminated, lifelong vitamin B 12 administration is usually recommended