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4.1.2 Divalent metal ion transporter 1 (DMT1) DMT1 plays a crucial role in the transport of iron ions, and its abnormal expression in OA patients is closely associated with disease progression

For UA conjugated metabolites, glucuronidation enhances the molecules hydrophilicity, promoting renal excretion, whereas sulfation may attenuate the biological activity of the UA monomer

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In vivo assessments employ histopathology, serum biochemistry, organ fluorescence imaging, and multi-organ biodistribution analysis