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PGC-1 and its downstream regulatory factors (NRF-1, NRF-2, and TFAM) play a pivotal role in the regulation of the spinal cord, muscle, and adipose tissue of SOD1-G93A ALS model mice

and has served as an adviser for Kyowa-Kirin and Novartis

Treatment Control Nlel -AnglV Dihexa Number of spines/5(^m 22 39 44 % Con-elation VGLUT1 95.2 95.1 94.4 Number of spines/5C^m 19 31 37 % Correlation Synapsin 93.4 94.2 96.3 Number of spines/5C^m 18 36 43 % Correlation PSD-95 98.03 97.38 98.71 The total number of spines for each treatment group is indicated as the number of spines per 50 dendrite length

at institutions like the University of Zagreb and NIH-funded labs