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Similarly, transgenic mice with cardiac-specific expression of constitutively active Akt exhibited a significant downregulation of PGC-1 mRNA levels (Rowe et al., 2010

This analysis adds to the growing body of evidence surrounding the safety profile of GLP-1RA therapies and emphasises the need for continued monitoring in clinical practice

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Further, new studies now suggest patients taking GLP-1 drugs are twice as likely to develop Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION)