When thyroid hormone levels are low, metabolism slows, leading to: Reduced resting energy expenditure: The body burns fewer calories even during basic functions Fluid retention: Hypothyroidism causes mucopolysaccharide accumulation in tissues, leading to a specific type of swelling called myxedema Fatigue and reduced activity: Low energy levels make consistent exercise challenging Altered appetite signaling: Thyroid hormones influence leptin sensitivity and appetite regulation Insulin resistance: Hypothyroidism is associated with impaired glucose metabolism, making fat storage more likely (Duntas & Brenta, 2018, Thyroid ) Even with adequate levothyroxine replacement, many hypothyroid patients report difficulty losing weight
Questions to ask your provider Before your first injection, get clear answers to these questions
The American Society of Anesthesiologists, in their guidance released on June 29, 2023, recommends holding GLP-1 agonists for one week before the procedure in patients on weekly dosing, and one day before in those on daily dosing
Important safety considerations include the risk of hypoglycaemia when Ozempic is used with insulin or sulfonylureas (dose reductions of these medications may be needed)