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Specific examples of methylation in detoxification: Arsenic detoxification requires sequential methylation: arsenite to monomethylarsonic acid to dimethylarsinic acid (the excretable form), catalyzed by arsenic methyltransferase (AS3MT) using SAM-e R Mercury undergoes methylation by gut bacteria, converting inorganic mercury to more toxic methylmercury (this is detrimental methylation, not detoxification) R COMT methylation of 4-hydroxy catechol estrogens prevents them from forming reactive quinones that generate ROS and DNA damage R 6
It also promoted PINK1/Parkin-mediated mitophagy and inhibited the activation of NLRP3 inflammatory vesicles, thus improving mitochondrial damage and inflammatory response (81)
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In lieu of application to the SOCIETY OF PSYCHROMETRIC FOOLS you may wish to apply to the English PSYCHROLOUSIA SOCIETY
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