Osteoarthritis is also biologically heterogeneous, involving cartilage, bone, synovium, nerves, and systemic metabolic factors rather than a single disease pathway. Mandelbaum said there are lifestyle factors people can adopt to help lower the risk of osteoarthritis as well as its painful effects
Your plateau is lifestyle-related No medication, not semaglutide, not tirzepatide, can overcome consistently poor nutrition or extreme sedentary behavior
More serious but less common risks include pancreatitis, gallbladder disease, acute kidney injury (usually secondary to dehydration from gastrointestinal symptoms), and diabetic retinopathy complications, particularly in patients with pre-existing retinopathy who experience rapid improvement in blood glucose
84% of the reports of alopecia made to FAERS were from consumers, and only 16% were from healthcare professionals, making it likely that users were self-diagnosing and had not received a clinician-confirmed report of alopecia
