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IGF-DES and the IGF-1R Signalling Network The IGF-1R is a cell-surface protein evolutionarily related to the insulin receptor, and its biological actions are moderated by IGFBPs that bind and transport the ligand in circulation
Research Applications Maximum GH pulse amplitude studies: When peak somatotroph stimulation is the primary endpoint, GHRP-2 delivers values the other two cant match IGF-1 axis research: Robust and sustained GH elevation drives sustained IGF-1 upregulation useful in models tracing the complete GHIGF-1tissue signaling cascade Metabolic models: Body composition, adipose tissue lipolysis, and insulin sensitivity studies in diet-induced obesity where HPA co-activation is either controlled for or informative GHSR-1a pharmacology: Receptor characterization in knockout or mutant models where potent full-agonist engagement is needed to saturate the receptor Cardiac research: Preclinical evidence for GHSR-1a-mediated cardioprotective effects potentially through PI3K/Akt survival signaling in cardiomyocytes, independent of GH elevation GHRP-6: The Original Ghrelin Mimetic GHRP-6 is the compound that started all of this
doi:10.1530/eje.0.1390552 (source) National Center for Biotechnology Information
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