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Prolonged pathogen stimulation of the immune system, coupled with inhibition of regulatory cells such as macrophages, dendritic cells, and M cells, disrupts immune homeostasis, thereby instigating intestinal inflammation

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Historically, the use of beta-blockers in individuals with ATTR-CM raised concern because of dependence on heart rate to maintain cardiac output, chronotropic incompetence from amyloid infiltration of the conduction system, and autonomic dysfunction