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Individual variation in GLP-1 receptor density and sensitivity, baseline insulin resistance, metabolic rate, body composition, genetic factors affecting drug metabolism, concurrent medications or supplements, adherence to dietary and lifestyle recommendations, and starting weight all influence how quickly and dramatically you respond to semaglutide

Mild soreness or redness at the injection site is possible but typically resolves within a few hours

185 papers were identified of which 58 were duplicates and 118 were excluded (unrelated n=83, syndromic/genetic GHD n=17, non-English n=13, abstract n=1, case report n=1)