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10 Challenges in clinical translation and prospects for personalized therapy 10.1 Biomarker-driven patient stratification Currently, the diagnosis of tinnitus relies almost entirely on subjective self-report, as no objective biomarker has been validated for clinical diagnosis or patient stratification

Cognitive and Behavioral Inflexibility in Lurcher Mice In the conditional visual discrimination task, where the condition of getting a reward were reversed after acquisition trials, Lurcher mice adjusted their behavior according to the reversed task, but still made more errors than WT mice [175]

This displaced material can compress adjacent nerve roots, triggering pain, numbness, tingling, or weakness in the areas those nerves serve

Additional information Peer review information Nature Chemistry thanks Junjie Yao, Deju Ye and the other, anonymous, reviewer(s) for their contribution to the peer review of this work