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Key Points Aberrant c-MET pathway activation occurs frequently in gastrointestinal tumours and can result from multiple mechanisms, including c-MET protein overexpression, MET amplification or enhanced transcription and/or aberrant autocrine or paracrine secretion of HGF Activated c-MET signalling results in enhanced cancer cell proliferation, survival and invasion

Kesimpulan: Walaupun masih sedikit bukti yang meyakinkan mengenai penggunaan glutathione untuk terapi hiperpigmentasi dan masih banyak kontroversi terkait penggunaannya, beberapa data penelitian yang ada memberikan hasil yang cukup baik dan aman terkait penggunaan glutathione oral dan topikal

Schilling test

28 allocated in the intervention group and 26 in the placebo