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For starters, misaligned timing of treatment eligibility, treatment assignment, and start of follow-up (collectively termed time zero) will result in biased effect estimates.[1] These biases are not overcome by large sample size or adjustment for confounding bias

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So here's the frame we'd stand behind: L-carnitine may offer modest support for fat metabolism, performance, and recovery alongside a calorie deficit and consistent training not on its own, and not as a shortcut around either

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