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Additionally, it is now known that pro-inflammatory cytokines also hijack IGF-1 intracellular signalling by phosphorylating serine residues on insulin related substrate (IRS) molecules and hence impeding their binding to IGF-1R [124]
Unfortunately, various factors can deplete our glutathione levels, including aging, chronic stress, poor diet, pollution, toxins, and certain medical conditions
Common explanations include: Alcohol exposure , especially if intake has crept up during work travel, client dinners, or periods of poor recovery Medication effects , including prescription drugs that affect liver enzyme activity Supplement burden , particularly when someone is using multiple performance, fat-loss, or bodybuilding products without clear oversight Metabolic dysfunction , such as fatty liver or insulin resistance Bile duct or cholestatic problems , which become more concerning if ALP, bilirubin, itch, pale stools, dark urine, or abdominal pain are part of the picture That spread is why I do not read a raised GGT as a standalone verdict