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These functions require dynamic regulation of the PPP pathway that is achieved through hierarchical interactions between transcriptome, proteome and metabolome
While women in developing countries may display lean PCOS phenotypes with severe reproductive dysfunction, women in industrialized countries frequently present with obesity-associated insulin resistance and metabolic syndrome (7)
While these findings do not establish diagnostic biomarkers, they underscore the relevance of metabolic profiling in ASD and support further investigation into dietary strategies as adjunctive, individualized interventions
the presence of modifying factors
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