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Research on GLP-1 and GIP Activation In laboratory settings, GLP-1 receptor activation has been shown to enhance insulin secretion, reduce glucagon levels, and slow gastric emptying, all of which contribute to stabilizing blood glucose levels after meals

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Therefore, even if preclinical studies have shown a neuroprotective effect of caffeine in PD patients, the results of clinical studies are controversial, the results being dependent on the stage of the disease, chronic drug treatment, duration of treatment, and dose of caffeine