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in Cell Metabolism note that SIRT1 activation improves mitochondrial efficiency and promotes a shift toward lipid utilization for energy, which can be especially beneficial in endurance and fat-loss settings (Price et al., Cell Metabolism )

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Damage to myelin causes the neurological symptoms that sometimes accompany vitamin B12 deficiency: numbness, tingling, balance problems, and memory issues

We also thank commenters for their suggestions related to risk adjustment for social and demographic factors