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The GIP pathway does not make fat cells burn fat faster. Instead, early research suggests that tirzepatide helps fat tissue function more normally reducing inflammation, improving adipocyte insulin responsiveness, and increasing adiponectin , a hormone linked to healthier metabolic regulation

Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice

So whats the take-home message

Nausea typically peaks in weeks 24 and resolves significantly by week 68 as your digestive system acclimates to the medication