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SOUL has enrolled around 9640 patients with T2D and cardiovascular disease, cerebrovascular disease, symptomatic peripheral artery disease, or chronic kidney disease for 3.55 years [55]

These estimates were below the prespecified 80% threshold for colocalization

In healthy individuals, about 90% of TMAO is excreted by the kidneys

Some, but not all, studies in mouse models of Huntingtons disease have suggested that coenzyme Q 10 supplementation could improve motor performance, overall survival, and various hallmarks of Huntington's disease, i.e., brain atrophy, ventricular enlargement, and striatal neuronal atrophy (70, 71)