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They are a legitimate and expanding area of clinical research

Retatrutide adds GIP and glucagon receptor activation to the GLP-1 effects

Clinical Insights: Creatine in Calorie Deficits While most creatine research focuses on athletes, several trials demonstrate efficacy in lean mass preservation when calories are restricted: A meta-analysis in Nutr Metab showed that subjects in a 20-30% calorie deficit who took creatine maintained up to 60% more lean mass than non-supplemented controls over 8 weeks

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