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This physiological mechanism, which is useful for the post-translational modification of multiple proteins and for the regulation of signal and metabolic pathways, can turn harmful in case of oxidative stress, with the above-mentioned mitochondrial damage

Although our experience suggests that hydroxocobalamin does not cause clinically significant interference with non-invasive pulse oximetry, there is evidence to suggest that co-oximetric blood gas analysis with several unique analyzers may be altered in the presence of hydroxocobalamin, specifically with false elevations of carboxyhemoglobin and methemoglobin concentrations and underestimation of true oxygen saturation values.5 There is no available evidence regarding the accuracy of other commonly utilized oximetric monitoring modalities (e.g., cerebral oximetry) following hydroxocobalamin administration

Advanced nanocarriers can co-deliver multiple therapeutic agents

Results: A total of 140 patients (ALI: n = 44