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Application of nonselective blockers or a cocktail of channel-type selective blockers of VGCCs reduced calcium signals to 10%15% (Goldberg et al., Interaction of Factors Determining Calcium Dynamics in Interneurons Ultimately, dynamics of [Ca 2+ ] i in interneurons is determined by the interaction between multiple ligand-gated and voltage-gated sources of calcium influx described above as well as additional factors, such as calcium release from internal stores (e.g., Goldberg et al., Back-propagating APs, in addition to causing calcium influx via activation of VGCCs, can bidirectionally modify dendritic calcium signals produced by ligand-gated mechanisms

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Source: Gojkovic et al., 2021 How BPC-157 Protects Against Alcohol Damage Four mechanisms explain why BPC-157 works across so many organ systems simultaneously