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Obesity has impacts on cardiovascular disease outcomes through increased risk of coronary artery disease, heart failure (more prominent with preserved ejection fraction), cardiac arrhythmias (most significantly atrial fibrillation), sudden death, and venous thromboembolism [7]

Therefore, targeted enhancement of the GSH system along with prevention of ferroptosis in the myocardium is a promising therapeutic strategy

Each milliliter of solution contains 2 milligrams of semaglutide

In 2012, while investigating the mechanism of Erastin-induced cell death, Dixon and colleagues formally coined the term ferroptosis to describe this iron-dependent, lipid peroxidation-mediated form of regulated cell death ( Compared with other forms of cell death, such as autophagy, apoptosis, and pyroptosis, ferroptosis exhibits distinct morphological, biochemical, and immunological characteristics (Xia et al., 2025)