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For example, increased power in specific NREM oscillations associated with plasticity (i.e., spindles) correlate positively with changes in Ca 2+ activity in cortical dendrites (Seibt et al., 2017) and CaMKII phosphorylation in hippocampal neurons (3)

Enzyme-responsive carriers, such as matrix metalloproteinases (MMP)-cleavable block copolymers, exploit selective cleavage by tumor-overexpressed proteases (Vizovisek et al., 2021), achieving faster release than non-cleavable controls (Padmavathy et al., 2018)

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Its action is also regulated by binding to at least 6 small carrier proteins called IGF-I binding proteins, that bind to IGF-I in extracellular fluid and the circulation (Box 1)