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doi: 10.1111/j.1600-079X.2006.00407.x 89 Cordoba-MorenoMOSantosGCMuxelSMDos Santos-SilvaDQuilesCLSousaKDSet al

MErCuRIC1: a phase I study of MEK1/2 inhibitor PD-0325901 with cMET inhibitor crizotinib in RASMT and RASWT (with aberrant c-MET) metastatic colorectal cancer (mCRC) patients [abstract]

People with low B12 may experience: Persistent fatigue or low energy Weakness Brain fog, concentration issues, or memory changes Low mood or irritability Pins and needles, numbness, or nerve-type sensations Mouth ulcers or a sore tongue Paleness or shortness of breath (if anaemia is present) Some symptoms can become more serious if deficiency is prolonged, particularly neurological symptoms

Demonstrates greater fat mass reduction