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In many materials, melting requires breaking powerful chemical bonds that extend throughout the entire structure

Alban A, David SO, Bjorkesten L, Andersson C, Sloge E, Lewis S et al

Colah S, Trauner DA (1997) Tactile recognition in infantile nephropathic cystinosis

Thus, HCC cells can internalize extracellular proteins by increasing the expression of a membrane ruffling protein called EH domain-containing protein 2, leading to resistance to glutamine deprivation under hypoxic conditions 122