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Inconsistent products lead to inconsistent data, making it impossible to determine if the protocol itself is flawed or if the compound was simply inert

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Because TB-500 reaches all tissues rather than concentrating at one site, the dosing strategy focuses on sustaining a systemic therapeutic level across the cycle rather than targeting a precise anatomical location

Machado MMF, Bassani TB, Cppola-Segovia V, Moura ELR, Zanata SM, Andreatini R, Vital MABF (2019) PPAR- agonist pioglitazone reduces microglial proliferation and NF-B activation in the substantia nigra in the 6-hydroxydopamine model of Parkinsons disease