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Abbreviations BMI: Body mass index CV: Cardiovascular CVD: Cardiovascular disease GLP-1Ra: Glucagon-like peptide 1 receptor agonists HF: Heart failure HFmrEF: Heart failure with mildly reduced ejection fraction HFpEF: Heart failure with preserved ejection fraction HFrEF: Heart failure with reduced ejection fraction HHF: Hospitalization for heart failure LV: Left ventricle LVEF: Left ventricular ejection fraction LVMi: Left ventricular mass index NT-proBNP: N-terminal-pro brain natriuretic peptide NNT: Number needed to treat RAAS: Renin angiotensin aldosterone system RCT: Randomized clinical trials SGLT-2i: Sodium glucose transporter 2 inhibitors STEMI: ST-elevation myocardial infarction T2D: Type 2 diabetes References Iribarren C, Karter AJ, Go AS, Ferrara A, Liu JY, Sidney S, Selby JV

Clinical trials are ongoing, and it is only available through medically supervised settings

Contrave, a combination drug containing the opioid antagonist naltrexone and antidepressant bupropion, while effective for weight loss, had the highest rate of adverse effects of any of the medications evaluated in the meta-analysis