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NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer's disease

In biochemical and cellular research environments, ipamorelin functions as an agonist at the ghrelin/growth hormone secretagogue receptor (GHSR1a), which is expressed on pituitary somatotrophs

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Conversely, stressed or dying chondrocytes release DAMPs, apoptotic bodies, cartilage fragments, and pro-inflammatory mediators that further activate synovial macrophages and fibroblasts, maintaining a chronic synovitic state and perpetuating pain and swelling (Li and Sun, 2024)