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A 3-(4-nitronaphthen-1-yl) amino-benzoate analog as a bifunctional AKR1C3 inhibitor and AR antagonist: head to head comparison with other advanced AKR1C3 targeted therapeutics

The net effect is a half-life of approximately 2030 hours compared to the 1215 minutes of free native IGF-1, and a substantially elevated free peptide fraction that is available for receptor engagement

Heather Hofflich, a physician and endocrinologist at UCSD Health