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The histone site H2AK119 can also be mono-ubiquitinated by polycomb repressive complex 1 (PRC1) and Cullin4B-Ring E3 ligase complex (CRL4B) to repress target genes, and its role in tumorigenesis has been well characterized ( Bdnf promoters I, II, IV, and VI was reduced, indicating that H2AK119ub is involved in the BHBA-induced activation of Bdnf transcription