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It notes that women in perimenopause or menopause may respond differently to GLP-1 therapy than premenopausal peers, because estrogen-mediated changes affect appetite and glucose regulation

Preliminary findings point to possible contributions to astrocyte functioning and the regulation of brain-derived neurotrophic factor (BDNF), a molecule central to neuronal stability and neurogenesis

However, it was reported that high doses of parenteral vitamin C caused nephrotoxicity

A total of 165 ALDH7A1 pathogenic variants have been reported in the literature, but no clear genotype-phenotype correlation has been established