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Unintentional weight loss exceeding expected therapeutic goals, or inability to maintain adequate nutritional intake, requires assessment for excessive medication effect or other underlying conditions

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Dosing Comparison# Retatrutide Dosing# Based on Phase 2 clinical trial protocols (investigational only): Starting dose : 0.5 mg weekly subcutaneous injection Escalation : Gradual increase over 12-24 weeks to target dose (up to 12 mg) Target doses tested : 1, 4, 8, and 12 mg weekly Escalation rationale : Extended 24-week escalation for higher doses reduces GI side effects compared to faster 12-week escalation No commercial formulation exists

This is setting up a pitfall of a decline in metabolic health because of weight fluctuations