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69 Whilst some studies have found that neither exogenously added nor secreted insulin has any autocrine signalling effect, this remains an area of controversy

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In the brain, GLP-1 activates appetite control centers, increasing satiety and reducing food intake, which lowers the amount of glucose entering the bloodstream

After supply disruptions for semaglutide and tirzepatide ended, facilities continued producing glucagon-like peptide-1 receptor agonists (GLP-1 RAs) using compounded formulations that include added ingredients, according to a study published in JAMA Health Forum (doi:10.1001/jamahealthforum.2026.2207)