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In addition to systemic benefits, as early as 1940, it was observed that riboflavin could also have local benefits: vaginal administration of riboflavin in ten women via a lactose tablet was shown to result in an increased acidity and a favorable impact on vaginal bacteria through increased growth of acid-forming bacilli and decrease of pathogens 78

Circulation 114 , 24742481 (2006)

3.5 Protein phosphorylation Protein phosphorylation, a critical post-translational modification, plays a pivotal role in the pathogenesis of PCOS by modulating signal transduction, enzyme activity, and cellular functions

Preventing this decrease, with the administration of a SIRT-1 activator, reversed ROS bursts, increased downstream nuclear PGC-1a and Nrf2 expression, and attenuated increases in mitochondrial membrane potential and neuronal apoptosis induced by ischemia/reperfusion injury [78]