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Dose-Pause and Discontinuation Patterns Phase 1/2 protocols allowed dose-interruption for severe injection-site reactions, IGF-1 elevations above protocol thresholds, and protocol-defined laboratory abnormalities

Patients who maintain their results beyond 12 weeks are those who adjusted caloric intake downward as weight decreased, incorporated refeed days to manage leptin suppression, and understood that the injections support the process but don't override thermodynamics

Unfortunately, most of these markers are only useful for advanced disease, so recent attention has focused on DNA methylation biomarkers for early screening of OC

A statement like Ipamorelin adds GH without much cortisol is supported by pharmacology